陈成彬《细胞生物学》Crystal Structure of Mitochondrial Respiratory.pdfVIP

Cell, Vol. 121, 1043–1057, July 1, 2005, Copyright ?2005 by Elsevier Inc. DOI 10.1016/j.cell.2005.05.025 Crystal Structure of Mitochondrial Respiratory Membrane Protein Complex II Fei Sun,1,2 Xia Huo,2 Yujia Zhai,1 Aojin Wang,2 the oxidation of succinate to fumarate in the mitochon- Jianxing Xu,2 Dan Su,1 Mark Bartlam,1,2 drial matrix as succinate dehydrogenase. Succinate ox- and Zihe Rao1,2,* idation is coupled to reduction of ubiquinone to ubiqui- 1Tsinghua-IBP Joint Research Group nol at the mitochondrial inner membrane as one part of for Structural Biology the respiration electron transfer chain (Figure 1). Elec- Tsinghua University trons are transferred from succinate to ubiquinone Beijing 100084 through the buried prosthetic groups flavin-adenine di- China nucleotide (FAD); the [2Fe-2S], [4Fe-4S], and [3Fe-4S] 2 National Laboratory of Biomacromolecules clusters; and heme, which form an integral part of the Institute of Biophysics (IBP) complex (Hagerhall, 1997). Chinese Academy of Sciences Succinate:ubiquinone oxidoreductase normally con- Beijing 100101 sists of a soluble catalytic heterodimer and an integral China membrane region. The soluble catalytic heterodimer is made up of subunit A with a covalently bound FAD co- factor and subunit B containing three iron-sulfur clus- Summary ters: [2Fe-2S], [4Fe-4S], and [3Fe-4S] (Hagerhall, 1997).