臭氧治疗在治疗脑梗死中应用.pptVIP

臭氧自血回输在治疗急性脑梗死中的应用;臭氧自血回输在治疗急性脑梗死中的应用;前 言;前 言;前 言;前 言;臭氧的理化特性 ;医用臭氧发展简史;医用臭氧发展简史;臭氧治疗脑血管病的基础研究 ; 1. 氧化和氧饱和作用; 1. 氧化和氧饱和作用;2.臭氧对细胞和组织的作用;2.臭氧对细胞和组织的作用;2.臭氧对细胞和组织的作用;离体兔心脏;Chaudry‘s Experiment: 健康志愿者使用ATP;细胞外ATP供应;全血中的ATP;直肠吹入与全血中的ATP含量;[Can ozone administration activate the tissue metabolism?--A study on brain metabolism during hypoxic hypoxia]AU: Shiratori,-R; Kaneko,-Y; Kobayashi,-Y; Yamamoto,-Y; Sano,-H; Ishizu,-Y; Yamamoto,-TSO: Masui. 1993 Jan; 42(1): 2-6.JN: Masui; Japanese-journal-of-anesthesiology,-The;IS: 0021-4892LA: Japanese; Non-EnglishMA: As it was thought that the tissue metabolism could be activated by administration of ozone, the influence of ozone on cerebral metabolism was studied under hypoxic condition. Ozone 1.5% was obtained from an ozonizer which separates the ozone from oxygen. Objects were 30 mature rabbits and they inhaled 3% oxygen in 97% nitrogen (PaO2 17-19 mmHg) by spontaneous respiration through a tracheostomy cannula. Objects were divided into three groups. Control rabbits inhaled only anoxic gases without ozone administration. Although the oxygen group also inhaled anoxic gases, pure oxygen was administered through an A-V shunt, previously made on femoral artery and vein, with an oxygenator, named Nichidai style (counter-current-exchange method). Similarly, the ozone group was given ozone with the oxygenator via A-V shunt. In each group, survival time as well as ATP, ADP, AMP and lactic acid lipo-peroxide in brain were examined. After the administration of ozone, survival time was prolonged significantly, compared with the control group (P 0.005). Equally, ATP and energy charge in the brain were well maintained (P 0.005) and the lactate production was inhibited significantly (P 0.005). These results indicate that oxidizing effect of ozone will be beneficial to maintain energy charge in brain tissue during hypoxia. Further, ozone might activate the energy metabolism in animal tissues.RO: From-MEDLINE,-a-database-of-the-U.S