感染后肠易激综合征与溃疡性结肠炎缓解期病人直肠黏膜细胞因子的表达的论文.docVIP

　　感染后肠易激综合征与溃疡性结肠炎缓解期病人直肠黏膜细胞因子的表达的论文 作者：鞠辉，王光兰，张海燕，赵清喜，魏良洲，刘希双作者单位：青岛大学医学院附属医院, 山东 青岛 266003 内镜诊疗科; 消化内科 【摘要】 目的 探讨感染后肠易激综合征（piibs）与溃疡性结肠炎（uc）缓解期病人肠黏膜细胞因子的表达，从神经免疫机制分析肠易激综合征（ibs）与炎症性肠病（ibd）的相关性。方法 piibs组病人20例，uc组病人45例，正常对照组30例，结肠镜下取直肠黏膜标本，采用免疫组化方法检测其肠黏膜细胞因子的表达情况。结果piibs病人直肠ifnγ、il2阳性表达高于对照组（χ2=14.012、13.931,plt;0.01），而与uc病人比较差异无统计学意义（χ2=2.290、2.323,pgt;0.05）。piibs病人直肠黏膜p物质（sp）强度均值高于对照组（t=3.722,plt;0.01），而与uc病人比较差异无统计学意义（t=1.643,pgt;0.05）。直肠黏膜ifnγ、il2阳性表达的piibs病人sp强度均值高于对照组（t=2.301、2.252,plt;0.05），与uc病人比较差异无统计学意义(t=1.574,1.676,pgt;0.05)。结论 piibs与ibd之间可能存在某种相关性。 【关键词】 肠易激综合征；结肠炎,溃疡性；p物质；细胞因子类 　the incidence of functional disorder of intestine isabout 22%～25% after the boptoms like ibs occur in some patients or parasite, have been eliminated and the mucosal inflammation vanished, e (piibs)[1]. in remission, clinical manifestations of uc often resemble irritable boe (ibls), inal pain and diarrhea ical abnormality. the therapeutic efficacy is not satisfactory inosalicylic acid alone[2]. a folloucosa of patients ission, analyze the association betmunomechanism. 　　1 materials and methods 　　1.1 case selection 　　according to rome criteria ⅱ[4], 45 diarrheaibs patients, 17 men and 28 en, the mean age ly recruited from outpatient clinic of gastroenterology at the affiliated hospital of qingdao university medical college. of , 20 eeting the romeⅱcriteria, ptoms, cured ission， 25 men and 20 en, mean age ent ptoms of abdominal pain and diarrhea similar to ibs but alities of the structure and biochemistry of digestive tract, no obvious signs of congestion, edema or exudation inosalicylic acid alone. thirty controls, 12 men and 18 en, mean age ent onths after electroresection of colon polyp and no abnormalities orrhoid due to slight bloody stools, ptoms and signs of digestive tract. no history of immunologically mediated disease or infection and no recent medication ethods 　　tucosa alin, and embedded in paraffin. a 4μm thick serial section ade for all paraffi