Kechuanning Plaster drug toxicity study of the skin.docVIP

 PAGE \* MERGEFORMAT 14 ‘Kechuanning’ Plaster drug toxicity study of the skin Author: Wong Jing, Guan Dongsheng, Chen Shuyan, Division soldier Abstract: Objective: To explore the ‘Kechuanning’ Plaster skin and drug safety. Methods: The skin of rabbits with acute toxicity test, healthy guinea pig skin irritation and skin allergy test to observe the ‘Kechuanning’ Plaster medication through the skin of the animal acute toxicity, irritation and allergy. Results: ‘Kechuanning’ Plaster on the integrity of the skin and damaged skin of rabbits did not cause acute toxic reactions; pairs of guinea pigs integrity of skin and broken skin with mild irritation, but after administration 48 h, this stimulation disappeared; intact skin of guinea pigs without sensitization. Conclusion: ‘Kechuanning’ Plaster of clinical drug safety, non-toxic. Keywords:: ‘Kechuanning’ Plaster; acute toxicity; skin irritation; skin allergy ‘Kechuanning’ Plaster of Gansu Traditional Chinese Medicine Professor Liu Shiqiong After years of clinical validation, combined with modern pharmacological studies, repeated screening made of pure Chinese medicine developed for external use acupuncture patches. Its application simple, economical, often for many years in the ‘dog days’ for the treatment of bronchial asthma and chronic bronchitis, is very positive effect. To study the drug’s safety, this experiment the ‘Kechuanning’ Plaster of animal skin and drug toxicity studies, and based product development provides a theoretical basis. 1 Materials 1.1 Experimental Animal 12 healthy adult rabbits, evenly divided male and female, weight 2.0 ± 0.5 kg (Animal Laboratory, Lanzhou Institute of Biological Products to offer qualified证号 : Medical action Zi No. 14-004); 36 healthy adult guinea pigs, male and female of all semi-, weight 300 ± 50 g 〔 Chinese Academy of Agricultural Sciences, Lanzhou Institute of Veterinary Animal labs, qualified证号 SCXK (Gan) 2004-0005〕 . 1.2 Experimental Drugs ‘Kechuanning’ P