1 - methyl-4-phenyl-1 ,2,3,6-tetrahydropyridine in mice on the C57BL behavior and striatal dopamine content in.docVIP

 PAGE \* MERGEFORMAT 20 1 - methyl-4-phenyl-1 ,2,3,6-tetrahydropyridine in mice on the C57BL behavior and striatal dopamine content in Abstract Objective: To observe the different doses of MPTP on mouse behavior and chest striatal dopamine, norepinephrine, 5 - HT and its metabolite levels to explore the MPTP mouse model of PD induced by the best conditions. : C57BL mice in each group were given a single daily dose MPTP different with different number of treatment administration were determined in mice in each group time to detect animal movement climbing pole coordination, locomotor activity counts measured evaluation of animal nerve excitability measured channel-type water official fan travel time for evaluation of spatial memory in mice. High-performance liquid chromatography animals striatum dopamine, norepinephrine, 5 - serotonin and its metabolites. To the fruit: In addition to the low dose group (20mg/kg), the other mice in each group after administration in the MPTP are different degrees pole climbing, prolonged reduction in the number of spontaneous activity, but the mouse channel-type water maze swim time in the no significant change before and after administration. MPTP treated group compared with the control group, dopamine (DA) and its metabolite (DOPAC) levels are significantly reduced. Noradrenaline (NA), 5 - hydroxytryptamine (5-HT) and its metabolite (5-HIAA) have not seen any significant changes. Conclusion: In addition to the low dose group (20mg/kg, continuous medication 3 days), each group can be caused by MPTP treatment of Parkinson’s disease-like symptoms in mice. MPTP-induced PD animal model in mice without obvious mental retardation. In such animal models should be based on the application of scientific research and the purpose of selection MPTP dose and route of administration. Keywords: 1 - methyl -4-phenyl -1,2,3,6 - tetrahydropyridine Parkinson’s disease dopamine in C57BL mice Mosquito-like body In recent years,