1,6 - diphosphate and citicoline combined treatment of neonatal hypoxic ischemic encephalopathy.docVIP

 PAGE \* MERGEFORMAT 5 1,6 - diphosphate and citicoline combined treatment of neonatal hypoxic ischemic encephalopathy [Keywords:] newborn, hypoxic ischemic encephalopathy, 1,6 - diphosphate, cytidine diphosphate choline Our hospital since 2006, application of 1,6 - diphosphate (FDP combined citicoline (CDPC treatment of neonatal hypoxic ischemic encephalopathy (HIE, a significant effect, are as follows. 1 Materials and Methods 1.1 General information on the selected case was in January 2006 ~ December 2007 in our hospital from full-term infants, age lt;24 h, a total of 68 patients, diagnostic criteria and sub-degree standard reference to the meeting in 2004 in Changsha, were randomly divided into two groups, the treatment group, 34 patients 23 males and 11 females. clinical classification: mild in 7 cases, moderate in 20 cases, severe in 7 cases. the control group of 34 patients, 21 males and 13 females, clinical degrees: mild in 6 cases, 21 cases of moderate and severe in 7 cases. two children with birth weight, asphyxia degree, mainly psychiatric symptoms, head CT, etc. The performance difference was not statistically significant (Pgt; 0.05 , comparable. 1.2 method two groups were given conventional symptomatic, supportive treatment, the treatment group on this basis, including oxygen, energy mixture (ATP, CoA, low dose mannitol 0.125 ~ 0.25 g / (kg · times, phenobarbital Zhijing 5 ~ 10 mg / (kg · times, to correct acidosis plus 1,6 - diphosphate 250 mg / (kg · times, 30 min during intravenous infusion, 2 times a day; citicoline added 0.125 g 50 ml 5% glucose solution in 1 day (to be bleeding in children with severe bleeding after the use of stability. were treated for mild to moderate 7 to 10 days, severe 10 to 14 days. Criteria of 1.3 markedly effective: Clinical symptoms completely disappeared within 7 days; effective: Clinical symptoms disappeared within 10 days; invalid: more than 10 days does not disappear. 2 Results Clinical ef