A new CD44 variant (CD44v17) in breast cancer tissues and its clinical significance.docVIP

 PAGE \* MERGEFORMAT 17 A new CD44 variant (CD44v17) in breast cancer tissues and its clinical significance Study: Jin Ling Gong, Wen-Lin Xu, Li Juan, Yang Jing, Wu Xiaojun, Chiao-Yun Chen [Abstract] Objective: To explore a new CD44 variant (CD44v17 in breast cancer tissues and its clinical significance. METHODS: According to our lab found in MCF 7/Adr a New CD44 splice variants CD44v17 shear (gene bank NO.FJ216964) design specific primers, fluorescent dye SYBR Green applications, real-time PCR detected 52 cases of breast cancer and corresponding adjacent tissues CD44v17 mRNA expression, calculated according to the standard curve CD44v17 mRNA expression analysis CD44v17 mRNA expression and biological characteristics of breast cancer between. Results: CD44v17 mRNA expression in breast cancer (3.10 + -1.12 was significantly higher than the corresponding normal tissue (2.31 + -0.84 (P lt;0.01, breast cancer lymph node metastasis (4.07 + -1.13 was significantly higher than those without lymph node metastasis (2.75 + -0.89 (P lt;0.01), tumorgt; 5 cm group CD44v17 mRNA expression (4.18 + -0.95 was significantly higher than tumor 5 cm group ( 2.96 + -1.07 (P lt;0.05), medullary carcinoma (5.27 + -0.30 was significantly higher than that of ductal carcinoma in situ (3.28 + -1.08 and invasive ductal carcinoma (2.92 + -1.04 (P lt;0.05), ductal carcinoma in situ and invasive CD44v17 mRNA expression in ductal carcinoma no significant difference (Pgt; 0.05, breast cancer clinical stage CD44v17 mRNA expression (4.18 + -0.92 was significantly higher than in stage (2.73 + -0.97, period (2.76 + -0.96 (P lt; 0.05), breast cancer CD44v17 mRNA expression of estrogen receptor, progesterone receptor (progesterone receptor, PR) and cerbB 2 expression was no significant correlation (Pgt; 0.05. Conclusion: CD44v17 mRNA is highly expressed in breast cancer, in breast cancer play an important role in the development, which may be breast cancer invasion, metastasis and prognosis