Acorus gramineus and 6542 on morphine-withdrawal rats Microcirculation.docVIP

 PAGE \* MERGEFORMAT 11 Acorus gramineus and 6542 on morphine-withdrawal rats Microcirculation Author: Liu Ping, Li Na, households Zhijie, Zhang Qiuyan, Ya-Long Wang [Abstract] Objective To observe the essential oil from Acorus gramineus and 654  2 (anisodamine) on morphine withdrawal in rats mesenteric microcirculation. Continuous incremental Methods 6 d after subcutaneous injection of morphine by naloxone reminder Addiction (0.5 mg / kg), the establishment of morphine withdrawal model, the pre-withdrawal groups, respectively Shichangpu, 654  2 plus Shichangpu group and 654 -- 2 rats to the volatile oil from Acorus gramineus (5 g / kg) and 654  2 (10 mg / kg), and then Bl  2000 observation of medical image analysis system Shichangpu and 654  2 on morphine withdrawal rat mesenteric microvascular tube diameter, blood flow velocity and capillary bleeding and blood leaking and so on. The results compared with morphine withdrawal group 654-2 group, plus Shichangpu Shichangpu group and 654-2 rat mesenteric microvessel diameter, blood flow velocity, as well as bleeding and blood leakage, etc. have improved to varying degrees, in which to 654-2 plus Shichangpu group to improve the role of the most significant (P amp;lt;0.01). Conclusion Shichangpu, 654  2 were able to improve mesenteric microcirculation of morphine withdrawal in rats, of which 654  2 plus the improvement of the role of essential oil from Acorus gramineus most obvious. [Keywords:] 6542 Shichangpu mesenteric microcirculation of morphine withdrawal Abstract: ObjectiveTo study the effects of Acrous tatrinowii Schott volatile oil and anisogamini hydrochloridum on mesenteric microcirculation in morphine withdrawal rats. MethodsA model of morphine withdrawal rats was established by gradually increasing dose of morphine via subcutaneous injection. Test group rats took anisogamini hydrochloridum (10 mg / kg) and extract from acrous tatrinowii schott (5 g / kg), before rats were injected with