Activated protein C resistance Progress in acute lung injury.docVIP

 PAGE \* MERGEFORMAT 18 Activated protein C resistance Progress in acute lung injury [Keywords:] acute lung injury in organ protection activated protein C Literature Review Acute lung injury (ALI is a common and serious complication, usually resulting in prolonged hospitalization and hospital mortality in critically ill patients, the treatment strategy study has been the focus of attention. In recent years, studies have found that the body by internal and external sources of combat, the coagulation system and inflammatory system over-activation in the systemic inflammatory response syndrome (SIRS in a central position, the interaction between promote the occurrence of ALI. activated protein C (activated protein C, APC is a natural anticoagulant substances, and protective effect of both a variety of cells, has been used for the treatment of severe sepsis can significantly reduce mortality in such patients. is related to the APC resistance ALI reviewed the research progress. 1 ALI mechanisms occur ALI is characterized by a variety of system or the lungs increased pulmonary vascular permeability after trauma, resulting in non-cardiogenic pulmonary edema, is difficult to correct the clinical manifestations of hypoxic respiratory failure, often requiring mechanical ventilation secondary support. Its simple defined as: (1 acute onset, usually shorter than 7 d, (2 severe hypoxemia, PaO2/FiO2 lt;300, if PaO2/FiO2 lt;200 was the extreme form of ALI - acute respiratory distress syndrome (ARDS, (3 anteroposterior chest X-ray shows diffuse bilateral pulmonary infiltrates with pulmonary edema (patchy, asymmetrical, may be associated with pleural effusion, (4 no left atrial pressure and pulmonary artery wedge pressure (PAWP lt;18 mmHg [1] (1 mmHg = 0.133 kPa. Lead to a common cause of ALI are: cardiopulmonary bypass, severe sepsis, thrombolysis in acute pulmonary embolism, lung transplantation and reperfusion, severe acute pancreatitis, and gastrointestinal tr