ADAM33 gene with asthma and New Development.docVIP

 PAGE \* MERGEFORMAT 13 ADAM33 gene with asthma and New Development Of: Xiongjun Yan, Jiang Zhuoqin, He Qijiang, Li Jifang [Keywords:] asthma, ADAM33 gene Bronchial asthma is a chronic disease, bronchial hyperresponsiveness in the state, as allergens or other factors caused widespread airway disease, manifested as chest tightness, coughing, shortness of breath. Pathogenesis of the reasons is allergic to the first exposure to allergens (antigens), the produce an immune globulin (antibody) and attached to the bronchial mucosa, when re-exposure to allergens, because of bronchial antibody - antigen reaction induced bronchospasm, mucosal edema and increased secretion , the formation of bronchial stenosis, causing ventilatory defect. allergens are inside and outside the two exogenous pollen, dust, animal protein, and many other medical history or family history of allergies, mainly endogenous metabolism of pathogens products, and more with respiratory tract infection, such as chronic bronchitis. transbronchial biopsy showed that patients with asthma airway smooth muscle hyperplasia, hypertrophy, these cells secrete large amounts of cytokines, thereby stimulating the synthesis of extracellular matrix proteins. 1 asthma-related gene Asthma is now considered a polygenic disease, environmental factors and genes in the common role has led to asthma. In the past decade, global scale in 11 large-scale genome-wide screening, search asthma or related phenotype of disease susceptibility gene or genes, multiple chromosomal regions have been found associated with asthma, including 1p36, 2q14, 4q13, 5q31, 6p24, 7p14, 11q13, 12q24, 13q14, 14q24, 16q23 ~ 21, 20p [1]. Positional cloning method that ADAM33 is the first asthma candidate gene. ADAM33 belongs to ADAMs family, ADAM family (A disintegrin and metallopro-teinase domain) are a class including the disintegrin domain and metalloproteinase domain of transmembrane proteins, in cell fusion , cell matrix adhesion