All-trans-retinoic acid anti-tumor effect of research.docVIP

 PAGE \* MERGEFORMAT 20 All-trans-retinoic acid anti-tumor effect of research Keywords: tumor retinoic acid digestion 0 Introduction Retinoic acid-type drugs, including vitamin A, natural and synthetic derivatives. Vitamin A (retinol) into the human body into a retinaldehyde, and then by oxidation into retinoic acid. Retinoic acid is essential to maintain growth and development of the material, especially in the promotion of growth and differentiation of epithelial tissue to maintain its normal functions play an important role. Retinoic acid structure from the ring end, multi-alkene peptide side chains and the polar end of the group composed of three parts, when this three-part structure of the different groups are each replaced, the availability of biological activity of different compounds. Retinoic acid compound is currently divided into three generations according to different structures: the first, took the polarity terminal is used by different groups; to second, took the ring end of the group changes; the third generation of retinoic acid is a polyene side chain changes in peptide , and because a different direction is divided into two kinds of carboxyl isomers, namely cis-retinoic acid and all-trans retinoic acid (all  trans retinoic acid, ATRA), in which all-trans conformation the most stable and common. Retinoic acid receptor belongs to the steroid compounds - hormone superfamily of nuclear transcription factor has been found in two major categories of receptors with retinoic acid combined effect mediated by retinoic acid, or retinoic acid receptor (RAR) and the retinoid X receptor (RXR). There are three RAR receptor subtypes (RARα, RARβ, RARγ), and RXR have three subtypes (RXRα, RXRβ, RXRγ). RXR and RAR receptors in each member have a number of isomers, such as RARα are α1, α2, RARβ with β1, β2 [1,2]. 1 inhibited proliferation and induce differentiation and apoptosis Retinoic acid receptor ligand-binding