Allogenic nerve graft rejection study the progress of the immune.docVIP

 PAGE \* MERGEFORMAT 16 Allogenic nerve graft rejection study the progress of the immune Study: Fan Bing Chen Keming, Xing-yan [Keywords:] nerve Peripheral nerve defects, whether in peace or war, are very common. Defect, the clinical choice for autograft, but since somatic limited sources, and to the donor site caused some dysfunction. Currently, the settlement nerve research has focused in two aspects: one is to study the use of muscle bridge, intravenous tube, silicone tube, tissue engineering and other alternatives, the first three results are not satisfactory, while the latter is still in the experimental stage, on the other hand is the study of allogenic nerve transplantation, it not only has other alternative materials like neural network does not have internal structure, conducive to nerve regeneration, and the wide variety of sources, the length can be obtained with a similar defect nerve graft, but there is immune rejection problems. Many scholars have been on allogeneic nerve graft immune rejection in-depth research, has made good progress, indicating that local injection has broad application prospects, do a review on this article. 1 pre-graft 1.1 The freezing method The donor nerve to be simple or repeated freeze deep freeze, re-melt processing, the Schwann cells (schwann cell, SC) activity decreased or inactivated, without injury to provide mechanical support for the axon regeneration and the base membrane channel, which will help axon regeneration. Qiu, root [1] to the donor nerve in rats at different temperatures (-196 ℃, -80 ℃, -40 ℃) and different storage time (20 min, 1,3 weeks) were frozen, room temperature The following rewarming, and then frozen, and then rewarming were repeated 5 times. for allogeneic transplantation found that the nerve ends and through the regeneration of axons grew into the far ends, and that the freezing temperature to -196 ℃ for good , save time for 3 weeks is better. and Fansa [2] It was found prese