Alzheimer acupuncture pretreatment on the expression of rat Wnt1.docVIP

 PAGE \* MERGEFORMAT 16 Alzheimer acupuncture pretreatment on the expression of rat Wnt1 Of: Zhou Hua Hung Shen Feng had Kongli Xiaoling Du Yanjun Chen Bangguo Wang Shuju Sun Guojie [Abstract] Objective To develop Alzheimer’s disease (AD rat model of AD model rats of acupuncture pretreatment on Wnt1 signal transduction pathway and its control mechanism for AD. Methods AD rats were randomly divided into normal group, sham operation group, model group, pre-moxibustion group, pre-EA group, pre-acupuncture and moxibustion group. by real-time quantitative PCR detection of Wnt1 gene expression. Results of model group decreased hippocampal Wnt1 signal abnormalities, with the normal group and sham significant difference between groups (P lt;0.01. The pre-moxibustion group, pre-EA group, pre-acupuncture and moxibustion Wnt1 hippocampus have different levels of signal enhancement. Conclusions The role of acupuncture AD control mechanism may be adjusted Wnt signal transduction pathway of learning and memory related enzymes and protein expression in the hippocampus play a role. [Keywords:] acupuncture, acupuncture pretreatment, senile dementia, Wnt1 signaling pathway [Abstract] Objective To establish rat models of AD to explore the pre disposal on the rat models of senile dementia Wnt signal transduction pathway, and reveal the mechanism of acupuncture treatment of AD.Methods All the rats were divided into normal, sham, model, pre moxibustion, pre electro acupuncture, pre electro acupuncture and moxibustion groups at random. Results Wnt1 gene singal expression was observed to weaken abnormally in model rats. There were significant difference between the model group and sham, normal groups (P lt;0.01), while the Wnt1 singal were reinforced in pre electro acupuncture, pre moxibustion and pre electro acupuncture groups in different degree. Conclusions The adjusting mechanism of acupuncture to prevent and cure dementia is likely to regulate the Wnt signal transduct