Alzheimers disease and vascular dementia proton magnetic resonance spectroscopy study.docVIP

 PAGE \* MERGEFORMAT 8 Alzheimer’s disease and vascular dementia proton magnetic resonance spectroscopy study [Abstract] Alzheimer’s disease (AD) and vascular dementia (VD) is the health of older people in the main two problems, diagnosis, rely mainly on clinical data, most of the subjective indicators, long-term existence of early diagnosis, differential diagnosis difficult. In this paper, proton spectroscopy in AD and VD in the early diagnosis and differential diagnosis research situation. [Keywords:] Alzheimer’s disease; vascular dementia; magnetic resonance spectroscopy Dementia is an acquired, persistent mental impairment syndrome, senile dementia include Alzheimer’s disease (Alzheimer’s disease, AD) and vascular dementia (vascular dementia, VD). AD is the older of the most common type of dementia, according to autopsy studies, 60% ~ 70% of the dementia of this type [1]. VD is the second most common type of dementia, accounting for about dementia types of 10% ~ 20% [2], AD and VD pathological processes are not identical, but the clinical manifestations, risk factors, pathology findings, imaging features there is a certain degree of overlap [3], in clinical practice difficult to accurately distinguish between long-standing difficulties in the differential diagnosis. MRI technology in vivo for morphological and functional studies for dementia research provides an effective tool. Proton magnetic resonance spectroscopy (1H-MRS) in recent years the development of non-invasive study of changes in brain imaging compounds, composition techniques, was to detect morphological abnormalities in patients with dementia before the biochemistry of early abnormal changes in a sensitive means. In this paper, AD and VD in the early diagnosis and differential diagnosis of such research are summarized below. 1 1H-MRS in dementia research methodology 1H-MRS there are two kinds of positioning technology, single voxel MRS and multi-voxel MRS, multi-voxel MRS also inc