Ambroxol and pulmonary surfactant therapy in hyaline membrane disease in preterm children compared the effect.docVIP

 PAGE \* MERGEFORMAT 9 Ambroxol and pulmonary surfactant therapy in hyaline membrane disease in preterm children compared the effect [Abstract] Objective To compare ambroxol and pulmonary surfactant (PS treatment of hyaline membrane disease in preterm children (HMD) of the patients. Methods 42 patients with HMD in preterm children were randomly divided into two groups on the basis of routine treatment observed 21 cases of ambroxol given 7.5 mg / kg, 6 hours 1, intravenous infusion pump applications, use 3 days, PS group, 21 cases with PS 108 mg, intratracheal administration, 3 days. Comparison of the two changes in blood gas analysis, outcomes, complications, hospital stay and costs. Results of the survival rate of the observation group and 76.2%, 81.0% in control group showed no significant difference (Pgt; 0.05, the observation group of hospital charges significantly lower than the control group (P lt;0.05, comparing the other indices were no significant differences (Pgt; 0.05. Conclusion ambroxol treatment of preterm children with HMD PS efficacy equivalent, but cheaper, ammonium bromide oxygen therapy for the primary hospital promotion. [Keywords:] Ambroxol, pulmonary surfactant, preterm children, hyaline membrane disease Preterm children with hyaline membrane disease (HMD is due to the lack of pulmonary surfactant (PS caused by the premature death of one of the main children. Application of PS treatment significantly improved survival rate of preterm children, but to be expensive, and endotracheal administration , large-scale application is difficult. ambroxol can promote the role of PS synthesis and secretion can be used to control HMD, and the low price, easy to use. We observed the effect of these two drugs are reported below. Materials and Methods 1. General information from January 2005 to December 2007 were treated in our hospital pediatric HMD in preterm children with a total of 42 cases, including 29 males and 13 females, 28 to 36 we