Allicin bladder cancer in mice in vivo and in vitro anti-tumor effects of experimental study.docVIP

 PAGE \* MERGEFORMAT 18 Allicin bladder cancer in mice in vivo and in vitro anti-tumor effects of experimental study 【Abstract】 Objective To understand the allicin on mouse bladder tumor anti-tumor effect and mechanisms. Methods The MTT test of allicin directly assessed the cytotoxic activity, animal experiments showed that allicin has significant in vivo anti-tumor effect, and measured using LDH release assay cytotoxicity. The results of allicin directly to the bladder tumor cytotoxicity. High-dose treatment group compared with control group, tumor growth rate was obviously inhibited (P lt;0.01), after treatment of allicin produced lymphocytes against B16 tumor cells. Conclusion of allicin on bladder cancer has obvious anti-tumor effect. This effect may be related to direct cytotoxicity and immune responses. Allicin may be an effective treatment for superficial bladder cancer cavity. Keywords: garlic; anti-tumor; bladder cancer The Experimental Research on the Antitumor Effect of Allicin on Murine Bladder Abstract: ObjectiveTo understand anti  tumor effect and mechanism of allicin on murine bladder.MethodsThe direct inhibition effects of allicin in vitro was evaluated by MTT Assay.Anti  tumor effect of allicin in vivro was determined by animal experiment. CTL activity of lymphocyte was measured by the release of endogenous lactate dehydrogenase (LDH). Results Allicin had significant direct cytotoxicity to bladder cancer cells. In high dose group, it showed a marked delay in the appearance and growth of tumors after sc injection compared with control group (P lt;0.01 ). The body generated the cytotoxic lymphocyte responses to B16 tumor cells after treated with allicin.ConclusionAllicin has a marked anti  tumor effect on bladder tumor.This effect may be related to direct cytotoxicity and immune response.It may be an effective intravesical treatment agent for superficial bladder cancer. Keywords:: Allicin; Anti  tumor ef