Allicin on mice infected with Toxoplasma gondii mucosal and systemic immune response in.docVIP

 PAGE \* MERGEFORMAT 10 Allicin on mice infected with Toxoplasma gondii mucosal and systemic immune response in Study: Man Ying Yuan, Xiu-Hua Liu, Geng Yansheng, in Chaoyun, Liu is not China, Tang Zhiyuan [Abstract] Objective The allicin treatment and Toxoplasma gondii infected mice untreated rat spleen lymphocytes, mesenteric PP node number, the number of intestinal lymphocytes in the skin (IEL and determination of immunity against further attacks infections, understanding the immune allicin function. Methods The mice were divided into treatment groups, the infected group and control group, with 5 104 unit / only the RH strain Toxoplasma gondii oral infection of mice, the day of treatment with garlic, 1 / d, continued 14 d, after treatment, mice were sacrificed 0,2,4,6,8,10,12 weeks off, note the number of splenocytes, mesenteric PP node, the number of intestinal lymphocytes in the skin (IEL, and with 1 106 pcs / only tachyzoites re-infected mice, observed survival. results in the observation period, the number of mesenteric no significant changes in PP node, spleen lymphocytes, IEL treatment group was higher than the number of infected and control groups to treatment 4, 6,8 weeks, significant differences (P lt;0.05). Determination of immunity to challenge infection and then showed that the survival rate in treatment group than the infected group and control group, the difference was significant (P lt;0.05). Conclusion allicin treatment oral Toxoplasma gondii infection in mice, can stimulate the immune tissue and improve the survival rate of re-attack the infection. [Keywords:] allicin, Toxoplasma gondii, infection, immunohistochemistry, survival Toxoplasma gondii (Toxoplasma gondii) is an intracellular parasite, can infect most hosts including people. Acute infection phase, the rapid tachyzoite proliferation in the body, the body mainly on the immune response mediated IFN- mediated cellular immunity [1]. chronic infection due to Toxoplasma gondi