Arsenic trioxide on human colon cancer liver metastases in nude mice the level of carcinoembryonic antigen.docVIP

 PAGE \* MERGEFORMAT 13 Arsenic trioxide on human colon cancer liver metastases in nude mice the level of carcinoembryonic antigen [Abstract] Objective: To explore the arsenic trioxide (As2O3 treatment of liver metastasis of human colon adenocarcinoma of nude mice after the serum, ascites and tumor tissue CEA (carcinoembryonic, CEA level. Methods: Naked in the establishment of human colon adenocarcinoma metastasis model of rat after 15 min (early treatment group, 10 d (mid-treatment group, 20 d (late treatment group and by intravenous injection of As2O3 (5 mg / kg d, and 10 d after the model established by intravenous injection of physiological saline as a control group. at 4 weeks after inoculation of cancer cells, collected blood, ascites and nodules, CEA levels were measured. Results: The early treatment group, the blood, ascites and malignant nodules were significantly lower than the control CEA group (P lt;0.01, late treatment group and control group was not statistically significant (Pgt; 0.05. Conclusion: Early application of As2O3 can reduce the nude serum, ascites and tumor nodules in the CEA level. [Keywords:] cancer colon cancer CEA arsenic trioxide metastatic liver tumors [ABSTRACT] Objective: To investigate the change of CEA levels of blood, ascites and cancer tissue with liver metastases from human colon adenocarcinoma treated with arsenic trioxide (As2O3. Methods: As2O3 (5 mg / kg d was injected through tail vein at 15 min (early treatment group, 10 d (middle treatment group and 20 d (late treatment group after the model of liver metastases from human colon adenocarcinoma in nude mice were established respectively. Physiological saline was injected through tail vein at 10 d after the model of liver metastases was established as a control group. Results: The CEA levels of blood, ascites and cancer tissue in early treatment group were significantly decreased compared with the control group (P lt;0.01; but, there was no difference between