Artificial liver in emergency medical applications.docVIP

 PAGE \* MERGEFORMAT 9 Artificial liver in emergency medical applications Keywords:: fulminant hepatic failure (FHF) artificial liver In clinical medicine, fulminant hepatic failure (fulminant hepatic failure, FHF) are very common, shock liver, acute severe liver injury, poisoning-induced liver injury, multiple organ dysfunction syndrome (multiple organ dysfunction syndrome, MODS), acute pancreatitis with serious damage to liver function, metabolic diseases can cause FHF. Because the majority of such patients degeneration and necrosis of liver cells, functional failure, severe metabolic disorder and accumulation of toxic substances, which in turn affect the liver regeneration, creating a vicious circle, relying on the cause of the current therapies, general symptomatic supportive therapy, and animal -derived hepatocyte growth factor, can not be compensated liver cell function, and thus high mortality rate, its treatment is the clinical problems to be solved. Is well known that liver tissue itself has very strong regenerative capacity in clinical liver failure for various reasons, difficult to treat due to the reason lies in the liver cells in patients with large or sub-massive necrosis, necrosis of the extent and speed is much greater than its residual liver cell regeneration ability, coupled with a combination of factors such as the role of endotoxin, so that no time necrotic liver tissue regeneration and repair of Erzhi patients died. In the context of emergency medicine, severe shock, the patient is more common, easy to develop into FHF after shock, or MODS. Severe liver trauma with chest or adjacent organ injury often can also cause severe FHF, abdominal injuries and shock liver, we also often leads to FHF. FHF is also a serious complication of hepatobiliary surgery, although the incidence is not high, but a high fatality rate. FHF occurs mainly after the surgery, often after the onset of death within 1 to 2 days. FHF is a common complication of acute