Atherosclerosis Research diagnostic isotope target.docVIP

 PAGE \* MERGEFORMAT 17 Atherosclerosis Research diagnostic isotope target [Keywords:] Atherosclerosis; molecular imaging; nuclear medicine, literature review Atherosclerosis (AS) is a blood vessel wall in chronic inflammatory diseases, based on lipids, inflammatory cells and connective tissue deposition in the arterial wall characterized by a chronic progressive disease. The slow development of the early usually without any symptoms until the following two conditions occur when the clinical symptoms: (1 lesion extended limit blood flow, and (2 erosion or rupture of the fibrous cap eventually lead to thrombosis. The majority of patients when the disease first manifested as myocardial infarction, stroke or cardiac death. Clinical studies have shown that patients with coronary atherosclerosis than half of sudden death and myocardial infarction is the primary clinical manifestations [1]. In addition, the traditional risk stratification method for patients classified as moderate risk, about 2 / 3, acute coronary syndrome who [23]. Therefore, it is clear we need better ways to early detection, early diagnosis AS, so as to achieve the purpose of early prevention of AS. Existing tools such as angiography, magnetic resonance angiography, CT angiography for the diagnosis of AS have a certain value. Plaques by intravascular ultrasound can determine the general composition, but all the invasive examination, the application is limited. Rely solely on these morphological changes in the plaque diagnostic tool only large enough to achieve a certain degree of vascular stenosis can play a role in early detection of metabolic disorders characterized by AS has its inherent limitations [4]. nuclear medicine imaging is Currently the only qualitative, quantitative tissue and organ blood flow reflect metabolic and functional changes in the imaging methods, and thus, the use of radionuclide labeled material in the middle of AS for the formation of imaging, from molecular l