Chronic schizophrenia patients with bilateral hippocampal proton magnetic resonance spectroscopy imaging.docVIP

 PAGE \* MERGEFORMAT 15 Chronic schizophrenia patients with bilateral hippocampal proton magnetic resonance spectroscopy imaging [Abstract] Objective Analysis by proton magnetic resonance spectroscopy (1H MRS in patients with chronic schizophrenia Biochemical changes in bilateral hippocampus. Methods patient group and control group 25 cases, the use of 1H MRS measurement of N acetylaspartate two doors bilateral hippocampal aspartate (NAA, choline (CHO and creatine - creatine phosphate compounds (Cr were calculated NAA / Cr and CHO / Cr ratio. the result of chronic schizophrenia patient group with bilateral hippocampal NAA / Cr of ratio (2.05 + -0.14 on the left and right 1.98 + -0.17, lower than the control group (2.19 + -0.13 on the left and right 2.17 + -0. 14, the difference was significant (P lt;0.01, while the CHO / Cr ratio in patients with chronic schizophrenia group (1.30 + -0.12 on the left and right 1.25 + -0.18, higher than the control group (1.04 + -0.15 on the left and right 0.95 + -0.13, the difference was significant (P lt;0.01. Conclusions of chronic schizophrenia patients with bilateral hippocampal neurons may exist in the absence or dysfunction, and associated with membrane phospholipid metabolism. [Keywords:] schizophrenia, hippocampus, magnetic resonance spectroscopy Abstract: Objective To explore metabolism changes of hippocampal region of patients with chronic schizophrenia by single voxel proton magnetic resonance spectroscopy (1H MRS). Methods 1H MRS examination of bilateral hippocampus was conducted in 25 patients with chronic schizophrenia and 25 cases healthy controls. Metabolisms of NAA, CHO, and Cr were examined and the ratios of NAA / Cr and CHO / Cr were calculated. Results The NAA / Cr ratio in patients (left 2.05 + -0.14, right 1.98 + -0.17) was significantly lower than that in normal controls (left 2.19 + -0.13, right 2.17 + -0.14) (P lt;0.05). The CHO / Cr ratio in patients (left 1.30 + -0.12, right 1.25 + -0.18) was