Clove technology gentiopicroside study pills.docVIP

 PAGE \* MERGEFORMAT 9 Clove technology gentiopicroside study pills Of: Yang Hailing, GUO Yan, Wang Jian, Li Yongji [Abstract] Objective To determine the clove preparation gentiopicroside Pills. Methods orthogonal design, from the extract and substrate composition, melt temperature, substrate ratio and other aspects of visits to pill weight variation, dissolution time casual , the appearance of three indicators of comprehensive quality test results on the analysis of variance, the optimal conditions for optimal preparation process. The results according to the test to determine the best process is: to PEG4000: PEG6000 = 4:1 as a substrate, cloves, bitter glycosides: matrix = 1: 4, the liquid temperature is 80 ℃. Conclusion The process consistent with the 2005 Edition lt;lt;Chinese Pharmacopoeiagt;gt; on the Pill preparation requirements. [Keywords:] clove bitter glycosides, pills, preparation techniques, orthogonal Abstract: Objective To establish the optimum preparation process for Syrigopicroside Dropping Pills. Methods The preparation conditions, such as the proportion between the extracts and matrix, dripping temperature, the ratio of matrix, were studied with orthogonal test. The obtained results were tested by three indexes, such as the variation coefficient of weight of pill, time limit of dissolution and appearance of the dropping pills with analysis of variance. The preparation process was optimized. Results The optimal technical conditions were as follows: the ratio of PEG4000 and PEG6000 as matrix was 4:1, the ratio of syrigopicroside to matrix was 1:4, and the dripping temperature was 80 ℃. Conclusion The preparation technology can meet the requirement for dripping pill specified in China Pharmacopeia (2005 Edition). Keywords:: syrigopicroside, dropping pill, preparation technology, orthogonal test Clove Iridoids (syrigopicroside) as iridoid compounds, a molecular weight of 494.5, mainly sweet clover plants from the dry leaves of