Dihydroartemisinin cream of Formulation and in vitro permeability_0.docVIP

 PAGE \* MERGEFORMAT 11 Dihydroartemisinin cream of Formulation and in vitro permeability Of: Du Feng, Li Rongsheng, Wangnai Jie, Qiu Lin, Zhang Bei, Liangbing Wen, Fu Guilan, Ye Zuguang [Abstract] Objective To screen dihydroartemisinin (DHA) ointment prescription and penetration enhancers. Methods in vitro percutaneous penetration test method, using high performance liquid chromatography of DHA in vitro penetration rate of the sample to inspect, and to accumulate DHA curve through the volume for in vitro transdermal, were fitted with the Higuchi equation. Results penetration rate to water-soluble ointment and carbopol as penetration enhancers Azone highest 27.262 μg / (h · cm2), Higuchi equation linear better. Conclusions The best formula for the water-soluble matrix DHA carbopol ointment prescription for the best penetration enhancers Azone. [Keywords:] dihydroartemisinin, ointment, transdermal test, penetration enhancers, high performance liquid chromatography Keywords:: Dihydroartemisinin, ointment, transdermal experiment in vitro; penetration enhancers, HPLC Dihydroartemisinin (dihydroartemisinin, DHA) for the artemisinin reduction product of artesunate, artemether antimalarial drugs such as intermediate products from [1], a strong and rapid parasite killing the role of the clinical onset and rapidly control the symptoms. In this experiment, DHA transdermal ointment prescription screening test methods and different penetration enhancers on the permeability of DHA study ointment for DHA transdermal delivery system (transdermal drug delivery system, TDDS ) preparation of reference. 1 Materials 1.1 Drugs and reagents Dihydroartemisinin standard (batch number 100184-200401, Pharmaceutical and Biological Products supplied), dihydroartemisinin pharmaceutical raw materials (batch number was purchased from Chongqing Huali Wu Ling Shan Pharmaceutical Co., Ltd.). Water high water, pure methanol and acetonitrile for chromatography