Domestic tirofiban in ST-elevation acute coronary syndrome patients of emergency PCI.docVIP

 PAGE \* MERGEFORMAT 10 Domestic tirofiban in ST-elevation acute coronary syndrome patients of emergency PCI Of: Pal Hatti, Zhang Baojian, Wu Gang, Li Lan, XU Li Shu [Abstract] Objective To evaluate the domestic tirofiban for ST elevation acute coronary syndrome (ACS) undergoing emergency coronary intervention (PCI) treatment safety and effectiveness. Methods diagnosed ST-segment elevation type of ACS patients before PCI, tirofiban and divided into control group, before surgery tirofiban plus tirofiban, and maintain the 72h. 30 days were observed in the composite end point occurred, ECG changes, postoperative bleeding events and platelet. Results within 30 days after administration of myocardial infarction, acute coronary intervention and then reconstruction, the incidence of composite endpoint, test group than the control group (3% vs 12%, but the difference was not significant), by ST segment electrocardiogram test to improve the situation better than the control group [(0.48 + -0.08) mV vs (0.40 + -0.06) mV, P lt;0.01], bleeding complications, thrombocytopenia, increased compared with the control group, but no significant difference . Conclusion Tirofiban can be made safe for patients with ST segment elevation ACS patients in the emergency PCI may further improve the ischemic electrocardiographic changes, and may reduce the 30-day mortality. [Keywords:] ST-segment elevation acute coronary syndrome; tirofiban; coronary intervention In recent years, more and more evidence-based medical research shows that the process of platelet thrombosis plays an important role, suppression and antagonism of platelet adhesion and aggregation to prevent thrombosis in acute coronary syndrome and then (ACS) of the key link. At present, aspirin plus clopidogrel plus heparin (LMWH) combined with conventional treatment of ACS has become a new type of platelet membrane glycoprotein GP b / a receptor antagonist, has also been used clinically, blocking the fiber fibrino