EB virus and gastric cancer Research_0.docVIP

 PAGE \* MERGEFORMAT 21 EB virus and gastric cancer Research [Keywords:] EB virus; gastric cancer; relationship; mechanism Incidence of gastric cancer in the world accounted for the second malignancies, various types of malignant tumors in China ranks the first, the occurrence and development involves many factors. EB virus (Epstein-Barr virus, EBV) is a double-stranded DNA virus, herpes virus type 4 and celebrities (human herpesvirus 4, HHV-4). who is the sole host of the virus, the global population of about 98% of adults carry the virus, but the incidence of infection is often asymptomatic or not. EBV is caused by malignant diseases such as nasopharyngeal carcinoma and lymphoma, the main pathogens, and its presence in the organization and expression of the form has long been reported, and since Burke first reported in 1990, Epstein-Barr virus and gastric cancer has been associated in recent years to domestic and foreign scholars on the EB virus-associated gastric cancer (EBVaGC) made a series of studies, and proposed a variety of relevant theories, but so far EB virus infection and the relationship between gastric cancer and its mechanism is not very clear. This paper will Currently on the EB virus and gastric cancer and gastric carcinogenesis mechanism reviewed in the paper. 1 EB virus and gastric cancer 1.1 EB virus structural features of EBV is the first found in the human tumor virus, was originally proposed by Epstein and Barr from the African Burkitt lymphoma found in cultured cells, is a human herpes virus type 4, is a subfamily are addicted to cell lymphotropic virus The oncogenic DNA viruses, double-stranded target cells infected with about 172 282bp.EBV There are 3 main forms: latent infection (1atent infection), lytic infection and defects of the infection. Among the most common way of latent infection, with more than 90% who were lifelong latent infection in EBV [1]. Most people infected in early childhood can EB virus, and bring lif