Effect of pravastatin on the central nervous system ischemic injury in neurogenesis.docVIP

 PAGE \* MERGEFORMAT 11 Effect of pravastatin on the central nervous system ischemic injury in neurogenesis [Abstract] Objective: To study the effect of pravastatin on the central nervous system ischemic injury in the role of neurogenesis. Methods: The intraluminal suture method in rats caused by transient middle cerebral artery ischemia, and the following time points after injury for S amp;amp; P valve Statins: after injury, 6 h, as well as post-injury, a day after injury, and by rotating 14 d. Experimental evaluation of neurological recovery after injury. In addition, through three staining (BrdU, DCX, NeuN) were studied statin drugs on the central nervous system, the role of neurogenesis after injury. Results: compared with the control group, experimental animals after experimental rotation rates significantly increased; pravastatin significantly increased the dentate gyrus and the subventricular zone of BrdU-positive cells, and increased dentate gyrus, subventricular zone and striatum of the BrdU / DCX-positive cells. Conclusion: The central nervous system injury in the early re-use low-dose pravastatin is relatively safe and can significantly improve the neurological functional recovery after injury . pravastatin could be induced in rat dentate gyrus and the subventricular zone neurogenesis and increased migration of neurons in the striatum of the number. [Keywords:] ischemia Pravastatin neurogenesis 0 Introduction Pravastatin has some neuroprotective functions, and can promote angiogenesis. But on the central nervous system cell regeneration and the role of migration has been reported rarely. In this experiment we mainly observed the pravastatin in the rat central nervous system ischemic injury in After the role of neuroprotection and neurogenesis. 1 Materials and methods 1.1 Materials 45 adult Wister rats, body weight 270 ~ 330 g, housed in day and night time is 12: 12 h keeping the temperature indoors, water and food intake of freedom. Application