Effects of valsartan on patients with liver cirrhosis serum angiotensin Ⅱ TGF-β 1 effects.docVIP

 PAGE \* MERGEFORMAT 5 Effects of valsartan on patients with liver cirrhosis serum angiotensin Ⅱ TGF-β 1 effects Author: Wu Ching-Yuan YANG Xiao-yun Li Shaoguang Qiu-Mei Li Li Wen Fan [Abstract] Objective: To investigate the effect of valsartan on patients with liver cirrhosis serum angiotensin Ⅱ (Ang Ⅱ ) transforming growth factor-β 1 (TGF-β 1) the impact and implications. Methods: 40 patients with cirrhosis were randomly divided into treatment group and control group of 20 patients, two groups were given conventional treatment, the treatment group on the basis of conventional therapy with valsartan plus 80mg / d, in the pre-treatment and treatment of six ELISA assay used on serum Ang Ⅱ , TGF-β 1. Results: The patients with liver cirrhosis before treatment serum Ang Ⅱ (167.84 ± 64.81vs 51.13 ± 15.95pg / l) and TGFβ 1 (181.12 ± 32.63 vs31.46 ± 10.39μ g / l) were significantly higher than healthy people, applications, after valsartan treatment Serum Ang Ⅱ (168.67 ± 69.03vs218.46 ± 74.79 pg / l) higher than that before treatment, while serum TGFβ 1 (182.22 ± 30.60vs121.77 ± 13.84 μ g / l) decreased compared with before treatment, the differences were significant. Conclusion: Angiotensin Ⅱ Ⅰ receptor antagonist valsartan can reduce the level of serum TGFβ 1 has a certain anti-fibrosis. [Keywords:] cirrhosis of the liver angiotensin Ⅱ transforming growth factor-β 1 Valsartan The Influence of Valsartan on Liver Cirrhosis in Serum Angiotension Ⅱ (Ang Ⅱ ) and Transforming Growth Factor-beta 1 (TGF-β 1) Abstract: Objective: To investigate the influence and clinical effect of valsartan on liver cirrhosis in serum Ang Ⅱ and TGF-β 1.Method: 40 liver cirrhsis patients were randomly divided into two groups: treatment group and control group, 20 cases in each group. The control group was treated with routine treatment, the treatment group, besides routine with treatment, was added valsartan 80mg/day. Before treatment and after 6 months ELISA techniques w