Endometriosis sICAM.docVIP

 PAGE \* MERGEFORMAT 2 Endometriosis sICAM [Keywords:] Endometriosis Changes of sICAM1 and sHLA Ⅰ in endometriosis and its significance [Abstract] AIM: To investigate the relationship between endometriosis (EMs) and the levels of soluble intercellular adhesion molecule1 (sICAM1) and soluble human leucocyte antigen1 (sHLA Ⅰ ). METHODS: Thirty serum and 30 peritoneal fluid (PF) of patients with EMs ( test group) and 30 serum and 30 peritoneal fluid of patients without EMs (control group) were studied. The levels of sICAM1 and sHLA Ⅰ were detected by enzymelinked immunosorbent assay (ELISA). RESULTS: ① Significantly higher levels of sICAM1 in serum and PF were observed in patients with EMs compared with those in controls (P0.05). ② The levels of sICAM1 in serum and PF were significantly different and the levels in earlystage EMs group were higher than those in advanced group (P0.05). ③ Serum sHLA Ⅰ cevel was lower in EMs group (P0.05) but the level in earlystage EMs group was higher than that in advanced group (P0.05). ④ There were no statistically significant differences in the levels of sHLA Ⅰ in PF between the patients and the controls (P0.05). CONCLUSION: Changes of sICAM1and sHLA Ⅰ may play a role in the genesis of endometriosis. [Keywords] endometriosis; HLA antigens; intercellular adhesion molecule1; enzymelinked immunosorbent assay [Abstract] Objective: To investigate the pelvic endometriosis (endometriosis) in peritoneal fluid and serum soluble intercellular adhesion molecule-1 (sICAM1), soluble human leukocyte antigen Ⅰ (sHLA Ⅰ ) level and the incidence of the disease . Methods: The ELISA for quantification of sICAM1 level, semi-quantitative detection of sHLA Ⅰ level. Results: endometriosis peritoneal fluid and serum sICAM1 and sHLA Ⅰ levels were significantly higher (P