Epidural analgesia peptideI on Tiger autograft spinal dorsal horn cfos expression.docVIP

 PAGE \* MERGEFORMAT 12 Epidural analgesia peptideI on Tiger autograft spinal dorsal horn cfos expression [Abstract] Objective To observe the epidural analgesic peptide Tiger I on the rat model of autologous nerve graft mechanical pain threshold and spinal cord dorsal horn c fos expression to explore the analgesic peptide Tiger I on nerve neuropathic pain . Methods Male Wistar rats were randomly divided into 60 A, B, C group, A group model for the nerve autograft group, B group plus autogenous nerve transplantation group Tiger analgesic peptide I, C group, sham group . were made of models, starting 27 d after detection threshold mechanical stimulation and c fos expression count. The results A, B and C groups, all data were significantly different groups, A group and B group c fos positive cells count and mechanical pain threshold were significantly different. Conclusions Tiger I can effectively reduce the analgesic peptide nerve regeneration of nerve pain, and promote improved nerve repair. [Keywords:] peripheral nerve injury, nerve regeneration, nerve pain, c fos, Tiger analgesic peptide I Abstract: Objectives To investigate the influence of huwena analegesic peptide I (HWAP I) on neuropathic pain of the regeneration nerve by observing the machinery pain threshold and c fos expression in sciatic nerve autograft rat model after applying HWAP I epidurally. Methods Totally 60 male Wistar rats were randomly divided into three groups: sciatic nerve autograft group (group A), sciatic nerve autograft with treatment of HWAP I group (group B) and sham group (group C). The machinery pain threshold and c fos expression were measured 27 days after the operation. Results All indicators in group A and B were significantly different from those in group C. Remarkable differences in machinery pain threshold and c fos expression were also existed between group A and B. Conclusions Appling HWAP I epidurally can significantly alleviate neuropathic pain of the regeneratio