Erythropoietin protective effect on the retina Research Progress.docVIP

 PAGE \* MERGEFORMAT 27 Erythropoietin protective effect on the retina Research Progress Abstract Erythropoietin is secreted by the kidneys of endogenous cytokines, recent research has found that the retina there are erythropoietin and its receptor, and in retinal ischemia and anoxia, as well as photo-damage Dengjun protective effect. In this paper, erythropoietin and its receptor in the production, structure and in retinal ischemia and hypoxia in the protection mechanisms are reviewed. Keywords: Erythropoietin Neuroprotection of retinal ischemia and hypoxia Study advance on the protective effect of erythropoietin on retina Abstract Erythropoietin is well known due to the important function in the erythrocytopoiesis, however, the recent studies have found that erythropoietin and its receptors also exist in retina and play a protective role during hypoxia / ischemia and light-induced retinal degeneration etc. The article reviews the development of erythropoietin and its receptors, structure and protective mechanism in retina. * KEYWORDS: erythropoietin; retina; protection 0 Introduction Many retina, optic nerve diseases such as age-related macular degeneration, retinal detachment, retinitis pigmentosa, retinal dysfunction diseases, optic nerve damage and so on, their common pathological mechanism of retinal ganglion cells, photoreceptor cells and other neuronal apoptosis, the ultimate leading to loss of vision, therefore, look for retinal optic nerve protective drug of great significance. In this paper, EPO (erythropoietin, EPO) and its receptor in the production, structure of the retina protection mechanisms and clinical application prospects are reviewed. 1EPO as well as the molecular structure of EPO receptor EPO is a sialic acid-containing acidic heat-stable (80 ℃) glycoprotein, from 165 amino acids, derived from the kidney and fetal liver, in the case of hypoxia, EPO may be more organs outside th