Escherichia coli AcrABTolC efflux pump mechanisms of expression regulation of Progress.docVIP

 PAGE \* MERGEFORMAT 18 Escherichia coli AcrABTolC efflux pump mechanisms of expression regulation of Progress Author: Ma Hongxia Ma Zhi-Hao Shu-qing Liu Yutang umbrella [Abstract] AcrAB  TolC efflux pump over-expression is the main reason causing multi-drug resistant Escherichia coli. AcrAB  TolC efflux pump expression levels are determined mainly by its positive regulator, negative regulatory factors, and the environment in the regulation of chemical substances. This paper reviews recent AcrAB  TolC efflux pump regulator research progress. [Keywords:] Escherichia coli; resistance; efflux pump; AcrAB  TolC ABSTRACT Overexpression of the AcrAB  TolC efflux pump is the major contributor to multidrug resistance of Escherichia coli. The expression level of the AcrAB  TolC efflux pump is principally regulated by its up  regulation factors, down  regulation factors and surrounding chemical materials, etc . This article reviews research progress of regulation factors of the AcrAB  TolC efflux pump for the past few years. KEY WORDS Escherichia coli; Drug resistance; Efflux pump; AcrAB  TolC Drug efflux pump is able to exclude harmful to the substrate outside of a group of bacterial transport protein, its overexpression can cause the mechanisms of antibiotic resistance of bacteria as early as the mid-70s in the 20th century, has aroused the concern of scientists [1]. According to amino acid sequence homology, usually bacterial drug efflux pump is divided into five super-family: facilitator (major facilitator, MF) family, multi-drug and toxic efflux (multidrug and toxic efflux, MATE) family, resistance-nodulation-division (resistance  nodulation  division, RND) family, small multi-drug resistance (small multidrug resistance, SMR) family and the ATP-binding cassette (ATP binding cassette, ABC) family [2], which, in addition to ABC Family efflux with ATP for the energy needed, the rest are proton pump energy needed for efflux [3]. E. coli is