Experimental liver fibrosis of Traditional Chinese Medicine Research.docVIP

 PAGE \* MERGEFORMAT 14 Experimental liver fibrosis of Traditional Chinese Medicine Research [Keywords:] Chinese medicine, anti-hepatic fibrosis, animal experiments, review Liver (hepatic fibrosis, HF) is a variety of pathogenic factors such as chronic hepatitis virus infection, schistosomiasis, chronic alcoholism, metabolic diseases, such as sustained cholestasis induced liver inflammation or tissue repair after injury in the process of compensatory response to extracellular matrix (ECM) deposition in the liver pathological excess. to prevent or delay the occurrence of HF is the treatment of various chronic liver diseases, prevention of cirrhosis of the key, but there is no ideal anti-HF clinical drugs. As the HF the mechanism is a complex network structure, a single part of the intervention is difficult to achieve the desired effect. In this context, the researchers turned to the Chinese medicine. Traditional Chinese Medicine clinical practice long-term prevention and treatment of liver accumulation of traditional Chinese medicine research to lay the anti-HF a solid foundation, and its multi-channel, multi-target, multi-level role of the characteristics in the anti-HF has demonstrated a unique advantage and has broad prospects. I now traditional Chinese medicine in recent years, anti-HF monomer and its active ingredient Experimental studies are reviewed. 1 to reduce inflammation of the liver cells HF is the inflammation or liver cell necrosis, fibrous dysplasia liver pathological process. Gao et al [1] using CCl4 induced HF, the Ginkgo biloba extract to intervene and set pieces Fufangbiejiarangan as a positive control group. The results show that Ginkgo biloba extract high, medium and low dose group and Fufangbiejiarangan HF chip can significantly reduce the serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and serum hyaluronic acid (HA), laminin (LN) content, the degree of liver inflammation and de