Fang Yang Bugan marrow model of Alzheimers disease cortical neurons and Nissl body RNA Quantitative Study.docVIP

 PAGE \* MERGEFORMAT 12 Fang Yang Bugan marrow model of Alzheimer’s disease cortical neurons and Nissl body RNA Quantitative Study [Abstract] Objective: To investigate the Bugan raising medullary side senile dementia model of spontaneous cortical neuron RNA and Nissl body effects. Methods: From 21-month-old Kunming mice were screened from a hair of senile dementia (memory impairment) rats were randomly divided into four groups namely, the blank control group (Alzheimer’s disease group), western medicine control group, raising Bugan marrow low-dose group, Bugan raise high dose marrow groups, a separate learning and memory in normal elderly group (aged normal group). Learning and memory was tested by jumping performance; brain tissue frozen sections, cell chemistry showed RNA within the cerebral cortex neurons and Nissl body, fully automated microscope image analysis system for quantitative detection of RNA-related brain areas, and Nissl body content. Results: Bugan raise significant improvement in pulp before being spontaneous senile dementia model of learning and memory impairment in mice, and significantly higher in the cerebral cortex pyramidal cells, and Nissl body RNA content, but its role has presented a certain degree of dose-effect relationship. Conclusion: Bugan raising medullary improvements to Alzheimer’s disease model of spontaneous learning and memory impairment may be related to the promotion of the mechanism regulating RNA metabolism in the brain cortex to improve learning and memory neurons in key brain areas related to the structure. [Keywords:] Alzheimer’s disease; Bugan raising pulp side; RNA; Nissl body; cerebral cortex; mice 〔 Abstract〕 Objective To investigate the effects of Bugan Yangsui formula on the RNA and Nissl Bodies of cerebral cortex neuron in aged dementia mice. Methods Spontaneous aged dementia mice were screened out from 21 months old Kunming mice and then were divided randomly into 4 groups, namely control, westernmedicine,