First-degree relatives of type 2 diabetes mellitus normal glucose metabolism in patients with insulin resistance of.docVIP

 PAGE \* MERGEFORMAT 14 First-degree relatives of type 2 diabetes mellitus normal glucose metabolism in patients with insulin resistance of Of: Jingai Yu, Li Xiuli, Xie Xuan, Zhang Chunhong, as Shuying, Yuan Xiaohong [Abstract] Objective To explore type 2 diabetes mellitus (T2DM) patients with first-degree relatives with normal glucose tolerance -cell function and insulin resistance, and analyze the factors related to insulin resistance. Methods T2DM patients with normal glucose tolerance first-degree relatives of 63 cases, According to insulin resistance insulin resistance index were divided into groups and non-resistant group, 30 healthy subjects were selected as normal control group. 93 cases of the selected objects blood pressure, blood glucose, insulin, blood lipids measured, and homeostasis model of insulin resistance index (HOMA-IR) and cell function index (HOMA-). Results diabetes first-degree relatives compared with the control group, insulin levels, HOMA-IR, HOMA- was significantly higher (P lt;0.05) , insulin resistance group BMI, diastolic blood pressure, triglycerides, postprandial blood glucose, HOMA- was significantly higher than non-insulin resistant group (P lt;0.05), correlation analysis showed that insulin resistance and body mass index, diastolic blood pressure, triglyceride ester, postprandial insulin was positively correlated (P lt;0.01, P lt;0.05), and fasting blood glucose, postprandial glucose, fasting insulin, systolic blood pressure, cholesterol, no significant correlation (Pgt; 0.05). Conclusion degree relatives of T2DM patients there islet -cell compensatory hypersecretion, insulin sensitivity in early fall have emerged and insulin resistance. insulin resistance with weight gain, diastolic blood pressure and elevated triglycerides. Tip of first-degree relatives with diabetes should be strictly controlled weight, blood pressure and blood lipid on the reduction of positive significance to T2DM. [Keywords:] first-degree re