Flavone on buckwheat flower and type 2 diabetes insulin resistance.docVIP

 PAGE \* MERGEFORMAT 13 Flavone on buckwheat flower and type 2 diabetes insulin resistance Of: Shangbao Hua, Han Shuying, Zhengli Kun, Zhu Lisha, Yang Yuanming, M. Vincent, Weihong Lei [Abstract] Objective To study the mosaic buckwheat flavonoids (TFBFL insulin resistance in type 2 diabetic rats, blood glucose, blood lipids and insulin resistance (IR effects, and to explore its mechanism. Methods emulsion fed oxygen and low dose IV pyrimidine injection method produced insulin resistance in type 2 diabetic model rats. the SD rats were randomly divided into normal group, model group, TFBFL high, medium and low treatment group, rosiglitazone (RSG treatment group. After 6 weeks of continuous intragastric , fasting blood glucose (FBG), glucose tolerance (OTGG, fasting insulin (FINS, serum total cholesterol (TC, triglycerides (TG, free fatty acid (FFA), glycosylated hemoglobin (GHb, insulin sensitivity index (ISI), and KITT . HE staining morphological changes of pancreas and kidney. The results compared with the control group, model group FBG, OTGG, FINS, TG, TC, FFA, GHb was significantly higher (P lt;0.05 or P lt;0.01, ISI evident lower (P lt;0.05 or P lt;0.01. Compared with the control group, flavonoids Buckwheat Flowers can FBG, OTGG, FINS, TG, TC, FFA, GHb decreased (P lt;0.05 or P lt;0.01 and increased ISI ( P lt;0.05 or P lt;0.01, showed a dose-dependent, high-dose group and the rosiglitazone similar. tissue HE staining under light microscope observation showed that rats, the pancreas and kidney structural abnormalities. TFBFL different doses can significantly improve the pathological changes. Conclusions TFBFL a dose-dependent increase in insulin sensitivity in type 2 diabetes, insulin resistance, the organ injury in diabetic rats has a protective effect. [Keywords:] buckwheat total ketone yellow mosaic insulin resistance in type 2 diabetes Abstract: ObjectiveTo study the effects of total flavones of buckwheat flowers and leaves on serum glucose,