Heartache posted on oxidative stress in dogs with acute myocardial infarction myocardial metabolism and ultrastructure.docVIP

 PAGE \* MERGEFORMAT 10 Heartache posted on oxidative stress in dogs with acute myocardial infarction myocardial metabolism and ultrastructure Of: Cui Xinming Wang Qiujing right Xia Cao Yan Gu Fen Liu Lvwen Wei Hang Lu [Abstract] Objective To observe the heartache paste (XTT on acute myocardial infarction in rats. Methods 30 dogs were randomly divided into 5 groups: sham operation group, model group, XTT low dose group, high dose group, positive control group. Ligation Canine left anterior descending artery (LAD copy acute myocardial infarction model, XTT affixed to the dog left chest near the armpit area, determined 6 h after administration of serum superoxide dismutase (SOD, lipid peroxide (LPO), free fatty acids (FFA, nitric oxide (NO content, myocardial ultrastructure changes observed by transmission electron microscopy. Results XTT can reduce serum FFA and LPO content and increase NO content and SOD activity (P lt;0.05,0.01, after myocardial infarction can be improved cell ultrastructure. Conclusion XTT can improve myocardial ultrastructure of ischemic myocardium with a significant protective effect, with enhanced antioxidant enzyme activity, reduce lipid peroxidation, to correct myocardial FFA metabolism, increase the level of NO. [Keywords:] hurt paste, myocardial infarction, ultrastructure, oxidative stress, cardiac / metabolism [Abstract] Objective To observe the protective mechanism of Xintong Tie (XTT) on acute myocardial infarction (AMI) in dogs. Methods Thirty dogs were divided into sham operation, model, low dose XTT (0.6 g), high dose XTT (1.2 g ) and positive control groups at random. An AMI model was set up by ligating left anterior descending branch (LAD) in anesthetic chest opened dog. The patch was pot on the left chest near the armpit of every dog respectively. The content of SOD, LOP, FFA and NO were determined after 6 h. The changes of myocardial ultrastructural were observed. Results XTT reduced the ultrastructural injuries i