Heme oxygenase1 in aluminum overload-induced neurodegeneration in the role of the.docVIP

 PAGE \* MERGEFORMAT 2 Heme oxygenase1 in aluminum overload-induced neurodegeneration in the role of the Author: Yuan Ye, Jian Guo Zeng, YANG Jun-qing, ZHOU Qi-xin [Abstract] Objective: To investigate the heme oxygenase  1 (HO  1) on aluminum overload-induced neurodegeneration and significance of the change. Methods: 75 male NIH mice, body weight 24 ~ 26 g, were randomly divided into control group, aluminum chloride, low-dose group (3.75 mg / d) and high-dose group (7.50 mg / d), each 25. from each group were taken by intraventricular injection of artificial cerebrospinal fluid, 1.25 g / L aluminum chloride, solution or 2.50 g / L aluminum chloride solution of 3 μ L / only, 1 / d, continuous 5 d, the establishment of neuronal degeneration model; to heme oxygenase (HO) activity and protein expression and HO  1 C dialdehyde levels, metal ion content and the evaluation of hippocampal morphological changes of the relationship between HO  1 in aluminum overload-induced neurodegeneration in the role. Results: Compared with the control group, the aluminum chloride groups were seen in hippocampal CA1 area cell layer thinning with marked pyknosis. HO  1 protein: aluminum chloride, low-dose group 0.24 ± 0.01, high-dose group 0.33 ± 0.01; iron ion content: low-dose group (31.34 ± 2.85) mg / g, high-dose group (54.01 ± 2.31) mg / g, compared with control group HO  1 protein, 0.10 ± 0.01, iron content (22.54 ± 4.48) mg / g significantly increased, the difference was statistically significant (P