Herbs on the regulation of glucocorticoid receptor Research Survey_0.docVIP

 PAGE \* MERGEFORMAT 22 Herbs on the regulation of glucocorticoid receptor Research Survey [Keywords:] traditional Chinese medicine, pharmacology, glucocorticoid receptor, review Glucocorticoid receptor (glueocorticoid receptor, GR) is a nuclear receptor superfamily member, is a ligand dependent transcription factors. GR exists in almost all the cytoplasm of nucleated cells, the molecular weight of 90 ~ 95 kD, its main function is mediated by glucocorticoid (GC) play a role. GC into the target cells, and cytosolic GR binding in the GC-GR complex formation, then enter the nucleus, and DNA, glucocorticoid response element combination, regulate the synthesis of the corresponding proteins, which play different biological effects [1]. research shows, GR number and affinity is one of the determinants of GC effects [2]. However, in both cultured cells in vitro, or in the animals, at the protein level or mRNA level, GC has a negative regulatory role of GR [3]. Thus, GR and the relationship between diseases and the regulation of GR has been a research focus. In recent years, Chinese medicine treatment in the clinical status of more and more attention, many scholars dedicated to the research of traditional Chinese medicine on GR. author of Chinese medicine on the different states a summary of the regulation of GR, trying to clarify the role of the part of the mechanism of traditional Chinese medicine, Chinese medicine as a reference for modern scientific applications. A regulation under stress Stress is the body of a noxious stimulus (stressor) made adaptive integrated response, mainly for the following hypothalamus - pituitary - adrenal (HPA) axis of the main exciting series of neuroendocrine responses, the purpose is to make the body resistance enhance, maintain and restore homeostasis. stress reactions, increased secretion of hormones, mainly the increase of GC levels, and stress reaction hazards one of the main body, it is by the body caused by high conce