Hui patients with hyperlipidemia CYP2C9 3 MSA2756G gene polymorphism.docVIP

 PAGE \* MERGEFORMAT 14 Hui patients with hyperlipidemia CYP2C9 3 MSA2756G gene polymorphism Of: Liju Yi, Jin Jing, Gao Peng, Du, Wang [Abstract] Objective To study the treatment of hyperlipidemia in drug-related genes CYP2C9 * 3, methionine synthase (MSA2756G) in the Ningxia Hui in the distribution of patients with hyperlipidemia and its relationships with hyperlipidemia. Methods amplified the introduction of restriction sites (ACRS) and polymerase chain reaction and restriction fragment length polymorphism (PCR RFLP) technique for genotyping in patients with hyperlipidemia. Results 180 Ming Ningxia Hui hyperlipidemic disease patients, CYP2C9 * 3 allele frequency was 3.33%, mutation frequency males (3.05%) than women (0.28%), the difference was significant (P lt;0.01), with the healthy control group (3.00%) compared the difference was not statistically significant (Pgt; 0.05); MSA2756G allele frequency 15.83%, significantly higher than the control group (10.25%) (P lt;0.05), gender difference was not found. Conclusion Ningxia Hui people carrying CYP2C9 * 3 gene type of men at greater risk of suffering from hyperlipidemia; MSA2756G may be a risk factor for hyperlipidemia. [Keywords:] hyperlipidemia; CYP2C9; methionine synthase; polymorphism; Ningxia Hui ABSTRACT: Objective To investigate the distribution of CYP2C9 * 3 and methionine synthetase (MSA2756G) genes related to drug therapy in hyperlipidemia patients of Ningxia region as well as its relation with hyperlipidemia.Methods Genotype was determined by using amplication created restriction sites (ACRS) and polymerase chain reaction restriction fragment length polymorphism (PCR RFLP) in hyperlipidemia patients.Results Among the 180 hyperlipidemia patients of Ningxia Hui population, the frequency of CYP2C9 * 3 alleles was 3.33% and mutation rate in men (3.05%) was significantly higher than that in women (0.28%) (P lt;0.01). However, the indexes mentioned above did not differ from those of the healt