Human renal clear cell carcinoma and significance of the expression of EGFRv.docVIP

 PAGE \* MERGEFORMAT 10 Human renal clear cell carcinoma and significance of the expression of EGFRv Of: a small section of art, Jian-Sheng Wang, Zhang Mingxin, Xia Peng [Abstract] Objective To detect the epidermal growth factor receptor mutation type (EGFRv ) in renal clear cell carcinoma tissues and its relationship with renal cell carcinoma, the development of the relationship. Methods Using immunohistochemistry and image analysis detected 80 cases of renal cell carcinoma and 24 cases of normal kidney tissue EGFRv expression levels were statistically analyzed and compared. The results of renal clear cell carcinoma and normal kidney tissue EGFRv expression of the positive rates were 46%, 8%. by Semi-quantitative analysis, both the average gray value EGFRv were 148.49 + -13.05 and 155.65 + -14.86, the difference was statistically significant (t = 2.13, P = 0.04), male and female EGFRv patients, the average gray value to 149.01 + -13.70 and 147.40 + -11.76, no significant difference between the two (t = 0.54, P = 0.59), EGFRv expression with age was no significant correlation (r = 0.01, P = 0.92). Conclusion EGFRvIII in renal cell carcinoma of the presence of high expression, and renal clear cell carcinoma, the development of a certain relationship. [Keywords:] epidermal growth factor receptor mutants (EGFRv ), renal clear cell carcinoma, immunohistochemistry, image analysis ABSTRACT: Objective To detect expression of epidermal growth factor receptor variant (EGFRv ) in human suprarenal epithelioma to explore its relation with the genesis and development of suprarenal epithelioma. Methods Immunohistochemistry and pathologic image analysis were used to semiquantitatively detect the expression of EGFRv protein in eighty human suprarenal epithelioma tissues and twenty-four normal renal tissues. Results Positive expression rate of EGFRv was 46% in human suprarenal epithelioma tissues and 8% in normal renal tissues. Their average gray scale values