Huang Jing Granules Dodder Tripterygium female reproductive damage induced ovarian damage and smad4 mRNA expression.docVIP

 PAGE \* MERGEFORMAT 11 Huang Jing Granules Dodder Tripterygium female reproductive damage induced ovarian damage and smad4 mRNA expression [Abstract] Objective Tripterygium glycosides (GTW on ovarian tissue smad4 mRNA expression and the Dodder and the intervention of Polygonatum. Methods 4-week-old SD female rats, the rats were randomly divided according to 3 groups, respectively control group, GTW group, the intervention group were sacrificed after 12 weeks fed with animal testing indicators. Results GTW number of ovarian follicles secondary minimum, and the control group were statistically significant (P lt;0.05, and the difference between the intervention group also statistically significant (P lt;0.01, control group and intervention group differences were not statistically significant (Pgt; 0.05, the number of luteal groups were compared the difference was not statistically significant (Pgt; 0.05.GTW group smad4 mRNA expression between the control group There were significant differences (P lt;0.01, and the differences between the intervention group was statistically significant (P lt;0.05, control group and intervention group, no significant difference (Pgt; 0.05. Conclusion female rats can take TwP cause pathological changes in ovarian tissue, which decreased smad4 mRNA expression may result in the female reproductive GTW damage one of the key points. Chinese dodder seed, Huang Jing can promote the process of repair. [Keywords:] Tripterygium glycosides, rats, ovary, reproductive damage Tripterygium glycosides (glycosides of Tripterygium wilfordii Hook. F, GTW is the root of the core from the plant Tripterygium extract the components of an effective [1], because of increasingly effective and reliable treatment of pediatric renal disease treatment of essential drugs one. GTW is no doubt the efficacy, but side effects can not be ignored, especially minors, whether with the drug can cause reproductive damage adult inconclusive. how to maximize the e