HPLC determination of Biyankang Chlorpheniramine Maleate Tablets content.docVIP

 PAGE \* MERGEFORMAT 8 HPLC determination of Biyankang Chlorpheniramine Maleate Tablets content [Abstract] [Objective] To establish a HPLC method for the determination Biyankang Chlorpheniramine Maleate Tablets content. [Method] Phenomenex C18 Gemini (250 4.6mm, 5u column, the column temperature was room temperature, methanol and heptane sodium acetic acid mixture (60:40 by triethylamine adjusted to pH to 3.5 as the mobile phase; flow rate of 1.0ml min-1, detection wavelength: 224nm. [results] chlorpheniramine maleate injection In 0.253g ~ 1.265g amount within the range of peak area was linear (r = 0.9993, average recovery was 99.50%, RSD = 1.6% (n = 5. [Conclusion] The method is simple, accurate and can be used as the effective method of quality control products. [Keywords:] HPLC; Rhinitis Tablet; chlorpheniramine maleate Abstract: [Objective] To establish an HPLC method for the quantitative determination of Chlorphenamine Maleate in Biyankang Tablets. [Methods] The determination was performed on Phenomenex C18 column with the mobile phase consisted of methanol mixed solution of sodium heptane sulfonate and glacial acetic acid ( 60:40, adjuseted to pH3.5 with triethylaminum at ambient temperature.The flow rate was 1.0ml min-1.The detection wavelength was set at 224nm. [Results] The method showed a good linear relationship within the range of Chlorphenamine Maleate 0.509g ~ 2.545g (r = 0.9993, n = 5.The average recovery was 99.50% with RSD = 1.6% (n = 5. [Conclusion] The method is simple and accurate and could be used for quality control of Biyankang Tablets. Keywords:: HPLC; Biyankang Tablets; Chlorphenamine Maleate Rhinitis Tablet for the clinical treatment of acute and chronic rhinitis commonly used Chinese medicine, from patchouli, fruit, geese are not grazing, Angelica, baicalin, chlorpheniramine maleate and other herb composition. So far not reported Finished Chlorpheniramine Maleate in the assay method, in order to better control produc