Hypoxia-inducible factor-1α and tumor progression.docVIP

 PAGE \* MERGEFORMAT 16 Hypoxia-inducible factor-1α and tumor progression [Abstract] hypoxia-inducible factor-1α (hypoxia-inducible factor-1α , HIF-1α ) expression profile of a wide range of tumors; while HIF-1α in tumor play an important role in the evolution, performance on the tumor cell immortalization, genomic stability, tumor angiogenesis, tumor cell energy metabolism, tumor autocrine growth factor signal transduction, tumor invasion and metastasis, and tumor drug resistance and so on all levels. HIF-1α has been identified as an important molecular target therapy for cancer target proteins. [Keywords:] hypoxia-inducible factor-1α ; tumor metastasis; molecular target HIF-1α in the lung, stomach, liver, kidney, esophagus, colon, breast, cervical and ovarian cancer, bladder cancer, oropharyngeal cancer, head and neck cancer, endometrial cancer, malignant melanoma, oligodendrocytes glial cell tumor and astrocytoma and other tumor cells abnormally high expression of all assume. In recent years, HIF-1α and tumor occurrence and development, invasion, metastasis and tumor drug resistance is particularly the relationship between the attention. Based on tumor cell culture and transplanted tumors (tumor xenograft) model of experimental pathology at the molecular level, revealing the progress of the HIF-1α in tumor plays an important role in evolution. 1 HIF-1α and tumor cell immortalization Immortalization of human tumor cells need for the TERT gene encoding the transcriptional activation of telomerase. TERT gene 5 ‘flanking region (flanking region) there is hypoxia-responsive element (hypoxia response element, HRE), the combination of HRE through, HIF-1α transcription activation of telomerase expression in order to achieve cell immortalization [1, 2]. 2 HIF-1α and genomic instability Compared with normal somatic cells, tumor cells for DNA damage repair capability has been greatly reduced [3]. Mismatches in DNA repair system (mismatch rep