Idiopathic thrombocytopenic purpura immune abnormalities New Development.docVIP

 PAGE \* MERGEFORMAT 24 Idiopathic thrombocytopenic purpura immune abnormalities New Development Abstract For a long time that idiopathic thrombocytopenic purpura is mainly the cause of antibody-mediated platelet destruction increased, but the mechanism of humoral immune abnormalities can not explain all the phenomena of disease. More and more studies have shown that abnormal cell-mediated immunity involved in the mechanism of platelet destruction. This review on the T-cell tolerance, T cells, abnormal apoptosis, T cells, abnormal activation, T cell subsets and their functional changes, T cell cytotoxicity, etc. are outlined. Keywords: Idiopathic thrombocytopenic purpura; T lymphocytes; cell-mediated immunity Advances of Research on Abnormality of Cell Immunity in Idiopathic Thrombocytopenic Purpura - Review AbstractIt was long believed that platelets are prematurely destroyed in the reticuloendothelial system by platelet autoantibodies in idiopathic thrombocytopenic purpura. However, humoral mechanisms cannot account for all observations made in this disorder, and it is increasingly evident that cellular mechanisms contribute to platelet destruction. In this review the toleramce of T cell, abnormality of T cell apoptosis, abnormal activation of T cells, T cell subtype and its function changes, and T cell-mediated cytotoxicity were summarized. Keywords:idiopathic thrombocytopenic purpura, T lymphocyte, cell-mediated immune Idiopathic thrombocytopenic purpura (idiopathic thrombocytopenic purpura, ITP) is no obvious exogenous cause of the clinical syndrome caused by thrombocytopenia. As early as the 16th century, ITP Ji Pi is defined as a clinical syndrome, while Harrington’s classic experiment in 1951 opened ITP immune studies. More than 50 years research focused on aspects of humoral immunity that ITP is due to platelet antibodies have been self-allergenic and sheets of nuclear phagocyte system phagocytic destruction.