Id1 in hepatitis B virus-related liver disease expression.docVIP

 PAGE \* MERGEFORMAT 11 Id1 in hepatitis B virus-related liver disease expression Of: Liu Yu Rui, Lin Meng new weapons have been reached [Abstract] Objective To investigate the DNA binding / differentiation inhibiting protein 1 (Id 1) in viral hepatitis, liver cirrhosis and hepatitis B virus infection in hepatocellular carcinoma (HCC Expression and clinical significance. Methods Immunohistochemistry SP Study of 40 cases of viral hepatitis, 30 cases of cirrhosis, HCC 65 cases and 40 cases of adjacent liver tissue in the expression of Id 1. Results Id 1 were upregulated in HCC, was positively correlated with the degree of differentiation (r = 0.550, P lt;0.001), and in the absence of metastatic tumor 5 cm tumor in the upregulated (P lt;0.05), Id 1 in viral hepatitis, liver cirrhosis and HCC, the expression, in Viral hepatitis B and hepatitis B cirrhosis and HCC HCC and the expression of the difference was statistically significant (P lt;0.05. Conclusion Id 1 in hepatitis B viral liver disease upregulated, the diagnosis of primary HCC and provide a theoretical basis for treatment. [Keywords:] inhibitor, immunity, cancer, liver cell; liver cancer, hepatitis B virus, liver cirrhosis Cirrhosis and hepatocellular carcinoma of hepatitis B virus (HCC occurred an important risk factor, it is reported that 80% of HCC patients are also suffering from cirrhosis of the liver, and liver of hepatitis B surface antigen positive patients was 63.2% [1 2], suggesting that persistent infection of HBV liver inflammation and liver fibrosis and cancer have a certain relationship between the formation. DNA binding / differentiation inhibiting protein 1 (inhibitor of differentiation / DNA binding 1, Id 1) is found in a 1990 kinds of differentiation inhibitory factor, can promote cell proliferation, involved in tumor angiogenesis, promote tumor growth and metastasis [3], but the role of the HCC was not clear. I chose chronic hepatitis B, liver cirrhosis and HBV infection The