IGF IGF R in colonic adenoma and its biological significance.docVIP

 PAGE \* MERGEFORMAT 12 IGF IGF R in colonic adenoma and its biological significance Of: Zhao Kai, Fan Yu, Shen Yan, Lixin Zhong, Zhang Xiaoping, YUAN Yong-Chong [Abstract] Objective: To investigate the IGF , IGF R expression in colonic adenoma and explore its biological significance. Methods: Immunohistochemical methods were used to detect IGF , IGF R, PCNA in normal colon mucosa (A, n = 20, low grade intraepithelial neoplasia group (B group n = 50, high-grade intraepithelial neoplasia group (C group n = 50 and colon cancer group (D group n = 20 in the expression, TUNEL assay of apoptosis. Results: IGF , IGF R, PCNA in colon cancer group and the high-level group intraepithelial neoplasia was highly expressed, no significant difference between them (Pgt; 0.05), respectively, and low grade intraepithelial neoplasia group, normal expression of colorectal mucosa were significantly different than (P lt;0.01), low grade intraepithelial neoplasia group, the high-level group of intraepithelial neoplasia, colon cancer group, the apoptosis index (apoptotic index, AI) decreased, and the pairwise There were significant differences (P lt;0.01). IGF , IGF R expression and proliferation index (proliferative index, PI was positively correlated with the AI #8203;#8203;into a negative correlation, PI, AI in the low-level intraepithelial neoplasia group IGF , IGF R negative and positive in the no significant difference (Pgt; 0.05), in the high-level intraepithelial neoplasia group were significantly different (P lt;0.01). Conclusion: IGF , IGF R abnormal expression and colorectal adenoma cancer are closely related, IGF , IGF R promote abnormal cell proliferation, inhibition of tumor cell apoptosis, carcinogenesis in the colon adenoma played an important role. [Keywords:] insulin-like growth factor ; insulin-like growth factor receptor; colorectal adenomas [Abstract] Objective: To observe the expression of IGF and IGF R in colorectal adenoma and investigate