Infants with congenital heart disease perioperative stress response and organ protection.docVIP

 PAGE \* MERGEFORMAT 7 Infants with congenital heart disease perioperative stress response and organ protection As China’s development of cardiac surgery, pediatric congenital heart disease has increased considerably. Infants because of age is small, light weight, combined with often associated with varying degrees of malnutrition, there is the immaturity of their own organ development, various compensatory dysfunction by surgical stress and the effects of cardiopulmonary bypass, perioperative catecholamine increased and high blood sugar and lactic acidosis on the heart, lungs, blood clotting Dengjun have a significant impact that can lead to heart and lung reperfusion injury, and thus causing organ damage and even failure. Therefore, this article from the depth of anesthesia, narcotic pain medicine, cardiopulmonary bypass, fluid management, perioperative oxygen concentration and the stress response and organ protection of that relationship are reviewed. A congenital heart disease the preoperative status of newborn children with central nervous system development in various organs at the latest, and many children with serious congenital heart disease before surgery has been brain tissue damage. Mahle, etc. preoperative children with congenital heart disease on the head MRI research data show that 25% of children with congenital heart disease already exist in cerebral cortex and basal ganglia lesions. In a number of left heart hypoplasia, aortic arch and main pulmonary artery fistula in children, due to the low brain perfusion and reduction of cerebral oxygen saturation before surgery have damage to the nervous system and therefore more vulnerable to perioperative stress response After the result of a further blow. Respiratory system, due to immature respiratory center, combined with cardiopulmonary bypass (CPB) and the stress response can affect the activity of pulmonary surfactant material, especially in newborns and infants, CPB easy to occur after the gas