Influenza viruses induce apoptosis factors in Progress.docVIP

 PAGE \* MERGEFORMAT 19 Influenza viruses induce apoptosis factors in Progress Keywords:: influenza virus Advance in the research of factors associated with cell apoptosis due to influenza virus infection. 10 years ago, the study of influenza virus found the virus in vivo and in vitro can cause cell apoptosis, influenza virus-induced cell apoptosis is not only conducive to better understanding of influenza virus pathogenesis, but also for the use of biological methods to treat malignant tumors prompt new clues. Are now working on influenza virus infection and apoptosis of the research are reviewed. An influenza virus infection induces apoptosis in host cells In 1993, Takizawa [1] such as found in cultured canine kidney cell line (Medin-Darby canine kidney, MDCK) and human cervical cancer Hela cells infected with human influenza A virus, the cells were condensed chromosomes, cohesion, apoptosis body formation, DNA electrophoresis showed a typical ‘ladder-like’ band and a series of apoptosis-specific changes, and thus the first time influenza virus can induce apoptosis in cultured cells in vitro. Subsequently, another reported that influenza virus could induce the trachea, bronchial epithelial cells, alveolar, and the occurrence of lymphocyte apoptosis [2] as well as the emergence of the chicken in vivo apoptosis [3]. With the in-depth research, Hinshaw [4], who found that various types of A influenza virus (bird, human, pigs, horses), and B-type virus can cause cell DNA breakage. They use the human bc1-2 apoptotic antagonist gene transfected MDCK cells, the virus also infected with transfected cells and non-transfected cells and found that transfected cells does not appear, and activity detection of apoptosis was significantly higher than non-transfected MDCK cells. These results are further evidence of influenza virus-induced apoptosis is one of the mechanisms of cell death. Experiments show that UV-inactivated virus can not be drug-induced apopto