Ischemic stroke and genetic polymorphisms of correlation in.docVIP

 PAGE \* MERGEFORMAT 12 Ischemic stroke and genetic polymorphisms of correlation in [Keywords:] ischemic stroke, apolipoprotein E, gene polymorphism The threat of stroke has become a major disease of our people healthy. With cerebrovascular disease molecular biology, genetics and other research progresses, look for ischemic stroke related research in recent years become a focus of disease genes, apolipoprotein E (ApoE) is important components of plasma lipoproteins, mainly by the liver synthesis and metabolism, with a variety of biological activity, not only with lipid metabolism and atherosclerosis are closely related, but also involved in the repair of nerve cells and immune regulation. ApoE gene polymorphism on disease and ischemic stroke in the relationship, there are still debates (1.) Recent studies have found that, ApoE genotypes on lipid metabolism, atherosclerosis and coronary atherosclerotic heart disease impact, while lacking in the brain Blood also play an important role in the damage, but its specific role remains unclear. This brief review of this area. 1 ApoE biology Apolipoprotein isolated from the plasma of a class of lipid binding and transporter function of specific proteins. ApoE is a liver cell and macrophage function of protein synthesis (2), mainly in very low density lipoprotein (VLDL) , chylomicrons (CM) and the CM residues, also stored in the vLDL, high-density lipoprotein (HDL) sub-class. ApoE is composed of 299 amino acid single polypeptide chain glycoprotein with a molecular weight of 37 kD. human 3 ApoE isoforms exist, namely ApoE2, ApoE3 and ApoE4.ApoE molecules there are two domains, carboxy-terminal lipid binding domain of function, amino-terminal domains with low-density lipoprotein (LDL) receptor completely combination. ApoE and LDL receptor interaction between the ApoE-rich lipoproteins for clearance plays an extremely important role in the ApoE-rich lipoproteins as a ligand receptor can also be combined with o