Levofloxacin prostatitis rats in the pharmacokinetic study.docVIP

 PAGE \* MERGEFORMAT 19 Levofloxacin prostatitis rats in the pharmacokinetic study Author: Ma Xiaolin Li Min Zhao Cui England [Abstract] Objective To study the pathological model of bacterial prostatitis, Levofloxacin (Levofloxacin Hydrochloride) in rats in vivo pharmacokinetics. Methods 36 rats were caused by bacterial prostatitis pathological model, a single dose of a gavage Oral Levofloxacin [80 mg / (kg * bw)]; using high performance liquid chromatography determination of plasma concentration, blood concentration limit of detection 0.001μ g/ml, and to DAS 2.0 pharmacokinetic software for the data analysis. The results of drug absorption in vivo process in line with a two-compartment model (weight = 1/CC), the main kinetic parameters and fitting equations are as follows: T1/2Ka of (45.294 ± 2.07) min, T1/2α of (63.963 ± 15.258) min , T1/2β of (280.535 ± 214.601) min, Tmax for the (50 ± 17.321) min, Cmax of (14.905 ± 3.143) mg / L, AUC (0-1440) for the (2 561.219 ± 430.592) (mg * min * L-1), Ka is (0.015 ± 0.001) min-1, MRT (0-1440) for the (196.865 ± 50.656) min, fitting equation: C = 66.697 * e-0.011t 6.031 * e-0.004t - 72.728 * e-0.015t. Conclusion Levofloxacin in bacterial prostatitis rat model rapidly absorbed, the blood concentration higher, widely distributed, to eliminate slow. [Keywords:] Levofloxacin pharmacokinetics of bacterial prostatitis in rats by high performance liquid chromatography Abstract: ObjectiveTo study the pharmacokinetics of Levofloxacin Hydrochloride in pathological model of rats with bacterial prostatitis. MethodsGive the drug to 36 rats with bacterial prostatitis model at a dosage of 80 mg per kilogram of body weight orally.Plasma Levofloxacin Hydrochloride concentrations were determined by high performance liquid chromatography, with a limit of detection of 0.001μ g of Levofloxacin Hydrochloride per milliliter of plasma.Plasma Levofloxacin Hydrochloride pharmacokinetic data were calculated by using DAS2.0 pha